A desensitization protocol to ganciclovir

A desensitization protocol to ganciclovir

Case report Hospitalized HIV-infected woman, 49 years-old, with AIDS, presenting with an active cytomegalovirus (CMV) gastrointestinal infection. On the second day of therapy with intravenous ganciclovir (250 mg, q12h), the patient developed an isolated pruriginous maculopapular exanthema localized to the torso and limbs. A hypersensitivity reaction to ganciclovir was suspected; by this time, a...

Desensitization to clopidogrel: a tailor-made protocol.

Clopidogrel is an antiplatelet drug widely used for treatment and prevention of a variety of cardiovascular diseases. We report a successful desensitization to clopidogrel in a 70-year-old Caucasian man with delayed hypersensitivity (HS) reaction. He developed lip, hand and foot swelling, erythematous papular non-pruritic lesions and arthralgias 2 weeks after starting treatment with clopidogrel...

394 Desensitization Protocol to Methotrexate

day. Conclusions: Symptomes and appearence of the disease suggested several diseases but the laboratory tests were normal, making the diagnosis more difficult, the supposed diagnosis did not fit properly for the patient age. Careful observation of patients and the disease, exfoliative cytology and a biopsy, microbiological investigations allow the diagnosis, ruling out erythema multiforme and d...

Desensitization to Mycofenolate Mofetil: a novel 12 step protocol.

The use of MMF has become standard practice in many solid organ transplant recipients due its efficacy and favorable risk profile compared to other immunosuppressants. There has been a single case report of successful MMF desensitization. However, this protocol did not follow current Drug practice parameters. We report a successful desensitization to MMF in a double heart-kidney transplant reci...

Allopurinol Desensitization: A Fast or Slow Protocol?